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It means the person at the other end has never opened it. One of the few things I don't like about this template is that it doesn't call your attention more forcefully to the fact that you have a message.
“I'm in favor of plagiarism. If we are to create a new Renaissance, the government should encourage plagiarism. When convinced that someone is a true plagiarist, we should immediately award them the Legion of Honor.” —Jean Renoir